- Plague pandemic in Europe
- Spread through the air and by fleas
- 25,000,000 to 50,000,000 deaths (30-60% of Europe's population)
- Possibly introduced to Europe during Siege of Caffa in Crimea and carried back by fleas on ships sailing through the Mediterranean Sea
- Known as second plague pandemic (first was plague of Justinian in 541 - 549 AD)