- Lagos, Nigeria: 26.6 million
- Cairo, Egypt: 22.1 million
- Kinshasa, Democratic Republic of Congo: 16.3 million
- Algiers, Algeria: 9.8 million
- Giza, Egypt: 9.2 million
- Luanda, Angola: 8.9 million
- Dar es Salaam, Tanzania: 7.4 million
- Khartoum, Sudan: 6.1 million
- Johannesburg, South Africa: 6.0 million
- Abidjan, Côte d'Ivoire: 5.5 million
- Alexandria, Egypt: 5.4 million
- Addis Ababa, Ethiopia: 5.2 million
- Nairobi, Kenya: 5.1 million
- Cape Town, South Africa: 4.8 million
- Yaoundé, Cameroon: 4.3 million
- Kano, Nigeria: 4.2 million
- East Rand, South Africa: 4.0 million
- Douala, Cameroon: 3.9 million
- Casablanca, Morocco: 3.8 million
- Ibadan, Nigeria: 3.7 million
- Antananarivo, Madagascar: 3.6 million
- Abuja, Nigeria: 3.6 million
- Kampala, Uganda: 3.6 million
- Kumasi, Ghana: 3.6 million
- Dakar, Senegal: 3.3 million
- Port Harcourt, Nigeria: 3.3 million
- Durban, South Africa: 3.1 million
- Ouagadougou, Burkina Faso: 3.0 million
- Lusaka, Zambia: 3.0 million
- Bamako, Mali: 2.8 million
* Population estimates are from between 2021 and 2023